Leper enlists in the army after being impressed ..

His other friend, Leper, joins and receives a Section 8 discharge for being considered "mentally unstable." Even though against the war, many of the boys do join the troops just to avoid being drafted to the front lines....

Throughout the book, we see Gene, Leper, and Finny’s views on the world change....

In the novel Gene describes Leper as "...the type of person who was most often and most emphatically surprised, by this and every other shift in our life at Devon."p.93.

After Gene changes his mind and they meet the ..

In the novel Leper says, "Everything has to evolve or else it perishes."p.125.

Inflammation is a particularly important and complex reaction to tissue injury, and is particularly important in fighting infection. Acute inflammation is generally a non-specific response triggered by the injured tissue cells themselves, as well as specialized cells of the innate immune system and previously developed adaptive immune mechanisms. A localized acute inflammatory response triggers vascular changes in the injured area, recruits pathogen-fighting neutrophils, and begins the process of developing a new adaptive immune response. Chronic inflammation occurs when the acute response fails to entirely clear the inciting factor. While chronic inflammation can lay a positive role in containing a continuing infectious hazard, it can also lead to progressive tissue damage, as well as predisposing (in some cases) to the development of cancer.

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These boys attend an all-boy’s school called Devon School. It is said that: "Devon is sometimes considered the most beautiful school in New England." "Devon was both scholarly and very athletic." Devon is where Gene Forrester, Phineas (Finny) and Elwin (Leper) Lepellier attend school. Author John Knowles sets the story during World War II. This time period makes the boys have to think about which branch of the military they want to enlist in....

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Cells and tissues may respond to injury and stress by specific mechanisms, which may vary according to the cell types and nature of the injury. In the short term, cells may activate specific genetic programs to protect their vital proteins and organelles from heat shock or hypoxia, and may activate DNA repair pathways to fix damage to chromosomes from radiation or chemicals. Hyperplasia is a long-term adaptive response of cell division and multiplication, which can increase the ability of a tissue to compensate for an injury. For example, repeated irritation to the skin can cause a protective thickening due to hyperplasia of the epidermis. Hypertrophy is an increase in the size of cells in a tissue in response to stress, an example being hypertrophy of muscle cells in the heart in response to increased resistance to blood flow as a result of narrowing of the heart's outflow valve. Metaplasia occurs when repeated damage to the cellular lining of an organ triggers its replacement by a different cell type.

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Pathology is a broad and complex scientific field which seeks to understand the mechanisms of injury to cells and tissues, as well as the body's means of responding to and repairing injury. Disease processes may be incited or exacerbated by a variety of external and internal influences, including trauma, infection, poisoning, loss of blood flow, autoimmunity, inherited or acquired genetic damage, or errors of development. One common theme in pathology is the way in which the body's responses to injury, while evolved to protect health, can also contribute in some ways to disease processes. Elucidation of general principles underlying pathologic processes, such as cellular adaptation to injury, cell death, inflammation, tissue repair, and neoplasia, creates a conceptual framework with which to analyze and understand specific human diseases.